NuShield® is a sterilized, dehydrated placental allograft designed to protect and support healing.
NuShield is a natural, resorbable placental barrier that works as a wound covering in a variety of acute and chronic wounds.1-5
The amnion and chorion are multi-layered tissues, with each layer performing a specialized function that contributes unique characteristics to the tissue as a whole.1 As a dehydrated allograft that retains all native layers, NuShield is a more complete, more versatile graft.3,7
The proprietary process for NuShield preserves the native amnion and chorion with the spongy/intermediate layer intact.3 NuShield also undergoes less manipulation than other dehydrated amnion allografts.8-10
NuShield may be applied as a wound covering to a variety of partial- and full-thickness acute and chronic wounds:
- Trauma Wounds
- Dehisced Wounds
- Pressure Ulcers
- Venous Leg Ulcers (VLU)
- Diabetic Foot Ulcers (DFU)
- Wounds with Exposed Bone and Tendon
- Hyaluronic Acid (HA)
- Transforming Growth Factor beta 1 (TGF-ß1)
- Hepatocyte Growth Factor (HGF)
- Interleukin-1 Receptor Antagonist (IL-1ra)
This process preserves numerous growth factors and cytokines with angiogenic, regenerative, and anti-inflammatory properties.11
In in vitro studies, NuShield:
- Contains 640 Proteins including growth factors, cytokines, and chemokines11
- Releases growth factors and cytokines12 important to the wound healing process3-5, 13
- Increases fibroblast and keratinocyte proliferation12
- Niknejad H et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
- Hopkinson A. et al. Amniotic Membrane for Ocular Surface Reconstruction: Donor Variations and the Effect of Handling on TGF-β Content. Invest. Ophthalmol. Vis. Sci. 2006;47(10):4316-4322. doi: 10.1167/iovs.05-1415.
- Data on file. Organogenesis Inc. DR-0001.
- Schultz_Extracellular matrix review of its roles in acute and chronic wounds_2005.
- Eming_Inflammation in Wound Repair: Molecular and Cellular Mechanisms_2007.
- McQuilling JP et al. Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes. Wounds. 2017;29(5):E36-E40.
- Data on file. Organogenesis Inc. DR-0004.
- Koob TJ et al. Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. 2014. J Biomed Mater Res Part B 2014:102B:1353-1362.
- Grafix Stravix Surgical Application Brochure, OS17004/REV01 2017.
- AmnioExcel Advanced Wound Care Brochure, 0668686-2-EN 2018.
- Data on file. Organogenesis Inc. DR-0003.
- McQuilling_Evaluation of Growth Factor Release and Stimulation of Proliferation of Wound Microenvironment Cells with Amnion/Chorion. Grafts_ Poster presented at SAWC_Fall 2017.
- Barrientos_Growth factors and cytokines in wound healing_2008.