NuShield® is a sterilized, dehydrated placental allograft designed to protect and support healing.

NuShield is a natural, resorbable placental barrier that works as a wound covering in a variety of acute and chronic wounds.1-5

The amnion and chorion are multi-layered tissues, with each layer performing a specialized function that contributes unique characteristics to the tissue as a whole.1 As a dehydrated allograft that retains all native layers, NuShield is a more complete, more versatile graft.3,7

Preserving the Native Structure

The proprietary process for NuShield preserves the native amnion and chorion with the spongy/intermediate layer intact.3 NuShield also undergoes less manipulation than other dehydrated amnion allografts.8-10

Wound Types and Intended Use

NuShield may be applied as a wound covering to a variety of partial- and full-thickness acute and chronic wounds:

  • Trauma Wounds
  • Dehisced Wounds
  • Pressure Ulcers
  • Venous Leg Ulcers (VLU)
  • Diabetic Foot Ulcers (DFU)
  • Wounds with Exposed Bone and Tendon

Preserving the Spongy Layer
The spongy layer is a rich source of specific growth factors and proteins beneficial to the wound healing process.2-4, 5-7 In an in vitro study the spongy layer in NuShield contained:7
  • Hyaluronic Acid (HA)
  • Transforming Growth Factor beta 1 (TGF-ß1)
  • Hepatocyte Growth Factor (HGF)
  • Interleukin-1 Receptor Antagonist (IL-1ra)
Preserving the Bioactive Factors

This process preserves numerous growth factors and cytokines with angiogenic, regenerative, and anti-inflammatory properties.11

640 Proteins Identified

This is not an exhaustive list.

In in vitro studies, NuShield:

  1. Contains 640 Proteins including growth factors, cytokines, and chemokines11
  2. Releases growth factors and cytokines12 important to the wound healing process3-5, 13
  3. Increases fibroblast and keratinocyte proliferation12
References
  1. Niknejad H et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
  2. Hopkinson A. et al. Amniotic Membrane for Ocular Surface Reconstruction: Donor Variations and the Effect of Handling on TGF-β Content. Invest. Ophthalmol. Vis. Sci. 2006;47(10):4316-4322. doi: 10.1167/iovs.05-1415.
  3. Data on file. Organogenesis Inc. DR-0001.
  4. Schultz_Extracellular matrix review of its roles in acute and chronic wounds_2005.
  5. Eming_Inflammation in Wound Repair: Molecular and Cellular Mechanisms_2007.
  6. McQuilling JP et al. Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes. Wounds. 2017;29(5):E36-E40.
  7. Data on file. Organogenesis Inc. DR-0004.
  8. Koob TJ et al. Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. 2014. J Biomed Mater Res Part B 2014:102B:1353-1362.
  9. Grafix Stravix Surgical Application Brochure, OS17004/REV01 2017.
  10. AmnioExcel Advanced Wound Care Brochure, 0668686-2-EN 2018.
  11. Data on file. Organogenesis Inc. DR-0003.
  12. McQuilling_Evaluation of Growth Factor Release and Stimulation of Proliferation of Wound Microenvironment Cells with Amnion/Chorion. Grafts_ Poster presented at SAWC_Fall 2017.
  13. Barrientos_Growth factors and cytokines in wound healing_2008.

 

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