Affinity is an aseptically processed, hypothermically stored fresh allograft with viable cells, growth factors/cytokines, and extracellular matrix (ECM). Like native amniotic membrane, Affinity contains:
- Viable cells, including epithelial cells, fibroblasts, and mesenchymal stem cells (MSCs)1-3
Preserving Important Mesenchymal Stem Cells (MSCs)
Affinity undergoes a proprietary process that preserves MSCs, as shown in the in vitro study.1
Research has suggested MSCs play an important role in the wound healing process by:6-10
- Regulating immune response and inflammation
- Secreting growth factors, cytokines, and matrix proteins
- Promoting an organized extracellular matrix
In Vitro Studies Have Shown That Affinity Growth Factors/Cytokines Release Similarly to Unprocessed Amniotic Membrane
Affinity: preservation of native amnion tissue
- The first and only fresh amniotic membrane
- The closest choice to native amniotic membrane2
- The fresh thinking you and your patients need
Affinity is human allograft tissue that is regulated as a Human Cells, Tissues, and Cellular and Tissue-Based Product (HCT/P) as defined by FDA 21 CFR Part 1271.
Affinity may be applied as a wound covering to a variety of partial- and full-thickness acute and chronic wounds:
- Trauma Wounds
- Dehisced Wounds
- Pressure Ulcers
- Venous Leg Ulcers (VLU)
- Diabetic Foot Ulcers (DFU)
- Wounds with Exposed Bone and Tendon
- Data on file. Organogenesis Inc.
- McQuilling JP et al. Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes. Wounds. 2017;29(5):E36-E40.
- Niknejad H et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
- Mamede AC, et al. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res. 2012;349:447-458.
- Ghatak S et al. (2015). Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. Int J Cell Biol, 2015, .
- Maxson S et al. (2012). Concise review: role of mesenchymal stem cells in wound repair. Stem Cells Translational Medicine, 1(2), 142-149.
- Otero-Viñas, M., & Falanga, V. (2016). Mesenchymal stem cells in chronic wounds: the spectrum from basic to advanced therapy. Advances in Wound Care, 5(4), 149-163.
- Nuschke, A. (2014). Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organogenesis, 10(1), 29-37.
- Chen L et al. (2008). Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS one, 3(4), e1886.
- Hocking, A. M., & Gibran, N. S. (2010). Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. Experimental Cell Research, 316(14), 2213-2219.