Affinity is an aseptically processed, hypothermically stored fresh allograft with viable cells, growth factors/cytokines, and extracellular matrix (ECM). Like native amniotic membrane, Affinity contains:

  • Viable cells, including epithelial cells, fibroblasts, and mesenchymal stem cells (MSCs)1-3

Preserving Important Mesenchymal Stem Cells (MSCs)

Affinity undergoes a proprietary process that preserves MSCs, as shown in the in vitro study.1

Research has suggested MSCs play an important role in the wound healing process by:6-10

  • Regulating immune response and inflammation
  • Secreting growth factors, cytokines, and matrix proteins
  • Promoting an organized extracellular matrix

 

In Vitro Studies Have Shown That Affinity Growth Factors/Cytokines Release Similarly to Unprocessed Amniotic Membrane

Affinity: preservation of native amnion tissue

  • The first and only fresh amniotic membrane
  • The closest choice to native amniotic membrane2
  • The fresh thinking you and your patients need
Wound Types and Intended Use

Affinity is human allograft tissue that is regulated as a Human Cells, Tissues, and Cellular and Tissue-Based Product (HCT/P) as defined by FDA 21 CFR Part 1271.

Affinity may be applied as a wound covering to a variety of partial- and full-thickness acute and chronic wounds:

  • Trauma Wounds
  • Dehisced Wounds
  • Pressure Ulcers
  • Venous Leg Ulcers (VLU)
  • Diabetic Foot Ulcers (DFU)
  • Wounds with Exposed Bone and Tendon

References
  1. Data on file. Organogenesis Inc.
  2. McQuilling JP et al. Proteomic Comparison of Amnion and Chorion and Evaluation of the Effects of Processing on Placental Membranes. Wounds. 2017;29(5):E36-E40.
  3. Niknejad H et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
  4. Mamede AC, et al. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res. 2012;349:447-458.
  5. Ghatak S et al. (2015). Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. Int J Cell Biol, 2015, [834893].
  6. Maxson S et al. (2012). Concise review: role of mesenchymal stem cells in wound repair. Stem Cells Translational Medicine, 1(2), 142-149.
  7. Otero-Viñas, M., & Falanga, V. (2016). Mesenchymal stem cells in chronic wounds: the spectrum from basic to advanced therapy. Advances in Wound Care, 5(4), 149-163.
  8. Nuschke, A. (2014). Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organogenesis, 10(1), 29-37.
  9. Chen L et al. (2008). Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS one, 3(4), e1886.
  10. Hocking, A. M., & Gibran, N. S. (2010). Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. Experimental Cell Research, 316(14), 2213-2219.

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