Oral Regeneration

Dermagraft® is an FDA-approved, bioengineered human dermal substitute indicated for the healing of diabetic foot ulcers (DFUs).1

Dermagraft helps restore the compromised wound bed and heal DFUs by providing metabolically active fibroblasts seeded on a bioabsorbable scaffold that produce many of the same proteins and growth factors that support the healing response in healthy skin: human collagen, extracellular matrix (ECM) proteins, and cytokines and growth factors.2,3,4 Through extensive research, Dermagraft has been proven to close more DFUs, faster both in clinical and real world settings.5,6,7

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  1. Dermagraft Directions for Use. Organogenesis. 2013.
  2. Roberts C, Mansbridge J. The scientific basis and differentiating features of Dermagraft. Can J Plast Surg. 2002;10(Suppl A):6A-13A.
  3. Hunt TK, Hopf H, Hussain Z. Physiology of wound healing. Adv Skin Wound Care. 2000;13(suppl 2):6-11.
  4. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366:1736-1743.
  5. Marston WA et al. Diabetes Care. 2003;26(6):1701-1705.
  6. Frykberg R et al. Adv Skin Wound Care. 2015;28(1):17-20.
  7. Kirsner RS et al. Poster presented at: the Symposium on Advanced Wound Care; October 17, 2014; Las Vegas, N.