What is Apligraf?

Apligraf is a unique, advanced treatment for healing. It is created from cells found in healthy human skin and collagen derived from cows. In fact, it looks like a thin piece of real skin. It is used to heal venous leg ulcers that are not healing after 4 weeks of treatment with standard therapies and diabetic foot ulcers that are not healing after 3 weeks of treatment with standard therapies.

Apligraf has 2 types of cells–an outer layer of protective skin cells and an inner layer of cells contained within collagen. Both types of cells contain substances similar to those found in human skin.*

Apligraf plays an active role in healing by providing to the wound living cells, proteins produced by the cells, and collagen, which are important for healing.

* Apligraf does not contain certain things found in human skin, such as pigment cells, cells from the immune system, blood vessels, hair follicles, or sweat glands.
How does Apligraf compare to other wound care products?

Apligraf is an FDA-approved product. In multiple controlled clinical studies, it has been shown to be an effective and safe wound treatment.

Studies showed that Apligraf heals more wounds than standard treatment alone. And does it faster. Many wound treatments passively manage the wound. Apligraf plays a more active role by delivering to the wound living cells, proteins produced by the cells, and collagen, which are important for healing.

Apligraf is the only product that's FDA-approved for both venous leg ulcers and diabetic foot ulcers, containing two different types of skin cells, combined with collagen.

After care

Apligraf typically requires no maintenance. Dressings are usually changed once a week by your doctor or nurse depending on your wound type. It is very important to keep your follow-up visits and to follow your doctor's directions carefully. If you have any signs of infection such as tenderness to the touch, redness, pain, heat, and/or swelling, contact your doctor immediately.

Insurance Coverage Information

For Medicare patients, Apligraf is reimbursed by CMS as skin substitute.

All commercial medical policies cover treatment with Apligraf for venous leg ulcers and diabetic foot ulcers.*

* The coverage information provided is for educational purposes only and shall not be construed as a statement, promise, or guarantee that all information is accurate or reimbursement will be received. Reimbursement requirements are subject to change at any time; therefore, check with your local payer regularly.
Patient Assistance Program

Organogenesis is committed to providing access to Apligraf for those most in need through The Apligraf Patient Assistance Program. This program can assist patients with limited financial resources who also have no public or private insurance coverage.

To be eligible for this Program, the patient must:

  • Be a U.S. resident
  • Supply proof of income (1040 Tax Form or SSI statement along with application completed and signed)
  • Have no public or private insurance coverage—this program is not a co-payment assistance program

Please note that eligibility is determined on a case-by-case basis. Please apply with the assistance of your health care professional who is treating you.

Download Venous Leg Ulcer Patient Brochure

Download

Download Diabetic Foot Ulcer Patient Brochure

Download

Contact us for more information about Advanced Wound Care products

Thank you. We are processing your request... We are unable to process your request at this time. Please try again later.

Thank you.

Your information has been received.

A representative will contact you within 1 business day.