Apligraf is an FDA-approved, bioengineered living cell therapy indicated for the healing of venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs).1

Source:
  1. Apligraf [package insert]. Canton, MA: Organogenesis Inc.; 2017.

 

Apligraf plays an active role in healing by providing the wound with living human skin cells, growth factors and other proteins produced b y the cells, and a collagen matrix.1 Specifically, Apligraf stimulates healing due to its tissue engineered structure, which includes an outer layer of protective skin cells (human epidermal keratinocytes) and an inner layer of cells (human dermal fibroblasts) contained within a collagen matrix.

Source:
  1. Data on file. Organogenesis Inc
Wound Types and Intended Use

Apligraf is indicated for use with standard therapeutic compression for the treatment of non-infected partial and full-thickness skin ulcers due to venous insufficiency of greater than 1 month duration and which have not adequately responded to conventional ulcer therapy.

Apligraf is also indicated for use with standard diabetic foot ulcer care for the treatment of full-thickness neuropathic diabetic foot ulcers of greater than three weeks duration which have not adequately responded to conventional ulcer therapy and which extend through the dermis but without tendon, muscle, capsule or bone exposure.1

Source:
  1. Apligraf [package insert]. Canton, MA: Organogenesis Inc.; 2017
Why Apligraf?

Apligraf is the first and only wound-healing therapy demonstrated in a randomized controlled trial that it can convert the VLU wound environment from a chronic (or non-healing) gene profile to an acute (or healing) profile.1-3

Sources:
  1. Apligraf [package insert]. Canton, MA: Organogenesis Inc.; 2017.
  2. Data on file. Organogenesis Inc.
  3. Stone RC, Stojadinovic O, Rosa AM, et al. A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers. Sci Transl Med. 2017;9(371):eaa8611. doi:10.1126/scitranslmed.aaf8611.

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